This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Doody, G. A.
Right arrow Articles by Muir, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doody, G. A.
Right arrow Articles by Muir, W. J.

The British Journal of Psychiatry 173: 145-153 (1998)
© 1998 The Royal College of Psychiatrists

'Pfropfschizophrenie' revisited. Schizophrenia in people with mild learning disability

GA Doody, EC Johnstone, TL Sanderson, DG Owens and WJ Muir
University of Edinburgh, Department of Psychiatry, Royal Edinburg Hospital.

BACKGROUND: It is reported that people with mild learning disability have a higher point prevalence of schizophrenia than the normal population, the reasons for which are unclear. METHOD: Thirty-nine subjects with mild learning disability and schizophrenia, 34 control subjects with schizophrenia and 28 control subjects with mild learning disability were seen. Interviews with relatives and carers were also conducted. Assessments were made of clinical variables, psychopathology, neurological 'soft' signs, IQ, memory and family history. Blood was taken for karyotypic analysis from comorbid subjects. RESULTS: The comorbid group had more negative symptoms, episodic memory deficits, soft neurological signs, epilepsy and receive more community supports than control subjects with schizophrenia. Comorbid subjects had a tendency to belong to multiply affected families and show high rates of chromosomal variants on routine karyotypic testing. CONCLUSIONS: Future work on the generality of schizophrenia should include people with premorbid learning disability, as a discrete subtype from whom valuable genetic aetiological clues may be obtained.


This article has been cited by other articles:


Home page
 Am. J. PsychiatryHome page
A. S. Bassett, S. W. Scherer, and L. M. Brzustowicz
Copy Number Variations in Schizophrenia: Critical Review and New Perspectives on Concepts of Genetics and Disease
Am J Psychiatry, August 1, 2010; 167(8): 899 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
V. A. Morgan, H. Leonard, J. Bourke, and A. Jablensky
Intellectual disability co-occurring with schizophrenia and other psychiatric illness: population-based study
The British Journal of Psychiatry, November 1, 2008; 193(5): 364 - 372.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
P. Tyrer
From the Editor's desk
The British Journal of Psychiatry, November 1, 2008; 193(5): 434 - 434.
[Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
E. C. Johnstone, D. G. C. Owens, P. Hoare, S. Gaur, M. D. Spencer, J. Harris, A. W Stanfield, V. Moffat, N. Brearley, P. Miller, et al.
Schizotypal cognitions as a predictor of psychopathology in adolescents with mild intellectual impairment
The British Journal of Psychiatry, December 1, 2007; 191(6): 484 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
W. J. MUIR, B. S. PICKARD, and D. H. R. BLACKWOOD
Chromosomal abnormalities and psychosis
The British Journal of Psychiatry, June 1, 2006; 188(6): 501 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Psychiatr. Treat.Home page
E. Smiley
Epidemiology of mental health problems in adults with learning disability: an update
Adv. Psychiatr. Treat., May 1, 2005; 11(3): 214 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. S. Bassett, E. W.C. Chow, P. AbdelMalik, M. Gheorghiu, J. Husted, and R. Weksberg
The Schizophrenia Phenotype in 22q11 Deletion Syndrome
Am J Psychiatry, September 1, 2003; 160(9): 1580 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Psychiatr. Treat.Home page
A. Hassiotis, P. Tyrer, and P. Oliver
Psychiatric assertive outreach and learning disability services
Adv. Psychiatr. Treat., September 1, 2003; 9(5): 368 - 373.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Psychiatr. Treat.Home page
M. Lindsey
Comprehensive health care services for people with learning disabilities
Adv. Psychiatr. Treat., March 1, 2002; 8(2): 138 - 147.
[Full Text] [PDF]

Home page
 BMJHome page
G. Doody and B. G R Neville
Mental health services for people with learning disabilities
BMJ, February 3, 2001; 322(7281): 301a - 301.
[Full Text]

Home page
 Psychiatr. Serv.Home page
K. E. Cherry, D. Penn, J. L. Matson, and J. W. Bamburg
Characteristics of Schizophrenia Among Persons With Severe or Profound Mental Retardation
Psychiatr Serv, July 1, 2000; 51(7): 922 - 924.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
W.I. FRASER
Three decades after Penrose
The British Journal of Psychiatry, January 1, 2000; 176(1): 10 - 11.
[Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
W. J. MUIR
Genetics advances and learning disability
The British Journal of Psychiatry, January 1, 2000; 176(1): 12 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
C. L. MORGAN, Z. AHMED, and M. P. KERR
Health care provision for people with a learning disability: Record-linkage study of epidemiology and factors contributing to hospital care uptake
The British Journal of Psychiatry, January 1, 2000; 176(1): 37 - 41.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
P. J. Harrison
The neuropathology of schizophrenia: A critical review of the data and their interpretation
Brain, April 1, 1999; 122(4): 593 - 624.
[Abstract] [Full Text] [PDF]